One in three Asians on clopidogrel is taking a pill that may not work for them.
CYP2C19 poor metabolisers face up to 6× the risk of stent thrombosis. Most patients on this drug have never been tested. A preventable failure, written in their genome since birth.
A common epilepsy drug. A common Asian variant. A fatal skin reaction nobody saw coming.
5 to 15% of South Asians carry HLA-B*15:02 — a single allele that turns carbamazepine into Stevens‑Johnson syndrome. A simple test before the first prescription would prevent it. Most patients are never offered the test.
Most monogenic diabetes is misdiagnosed as Type 1 or Type 2. For decades. With daily insulin.
An estimated 80% of MODY cases are mistaken for the wrong disease. Patients spend a lifetime on insulin when a single oral medication would work better. The right diagnosis exists in fourteen genes, waiting to be read.
Most couples marry without knowing whether they share a genetic risk that will appear in their children.
India carries the world's highest burden of inherited disorders — thalassemia, sickle cell, SMA, cystic fibrosis. Pre-marital and pre-pregnancy carrier screening is decisive. It is also, today, almost never offered.
A genetic reaction to common anaesthesia. Onset in minutes. Detectable in advance — if anyone bothers to look.
A rare but lethal reaction triggered by routine anaesthetic agents. The susceptibility is inherited and identifiable before the patient ever reaches the operating table. It is, today, almost never screened for.